Serdemetan Antagonizes the Mdm2-HIF1α Axis Leading to Decreased Levels of Glycolytic Enzymes

Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also regulates numerous proteins involved in diverse cellular functions. We investigated if Serdemetan would alter the Mdm2-HIF1α axis and affect cel...

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Detalles Bibliográficos
Autores principales: Lehman, Jason A., Hauck, Paula M., Gendron, Jaimie M., Batuello, Christopher N., Eitel, Jacob A., Albig, Allan, Kadakia, Madhavi P., Mayo, Lindsey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765416/
https://www.ncbi.nlm.nih.gov/pubmed/24040331
http://dx.doi.org/10.1371/journal.pone.0074741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765416/
https://www.ncbi.nlm.nih.gov/pubmed/24040331
http://dx.doi.org/10.1371/journal.pone.0074741

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