Abrogated Thioredoxin System Causes Increased Sensitivity to TNF-α-Induced Apoptosis via Enrichment of p-ERK 1/2 in the Nucleus

Thioredoxin (Trx) and thioredoxin reductase 1 (TR1) are among the major redox regulators in mammalian cells and have a wide variety of roles, including removal of intracellular reactive oxygen species (ROS) and prevention of cell death. Tumor necrosis factor-α (TNF-α) induces cancer cell death. Alth...

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Detalles Bibliográficos
Autores principales: Yoo, Min-Hyuk, Carlson, Bradley A., Gladyshev, Vadim N., Hatfield, Dolph L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765418/
https://www.ncbi.nlm.nih.gov/pubmed/24039713
http://dx.doi.org/10.1371/journal.pone.0071427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765418/
https://www.ncbi.nlm.nih.gov/pubmed/24039713
http://dx.doi.org/10.1371/journal.pone.0071427

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