Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines

BACKGROUND: Farnesyltransferase inhibitors (FTIs) are anticancer agents with a spectrum of activity in Ras-dependent and independent tumor cellular and xenograph models. How inhibition of protein farnesylation by FTIs results in reduced cancer cell proliferation is poorly understood due to the multi...

Descripción completa

Detalles Bibliográficos
Autores principales: Porcu, Giampiero, Parsons, Ainslie B, Di Giandomenico, Daniele, Lucisano, Giuseppe, Mosca, Maria Giovanna, Boone, Charles, Ragnini-Wilson, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765434/
https://www.ncbi.nlm.nih.gov/pubmed/23915247
http://dx.doi.org/10.1186/1476-4598-12-88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765434/
https://www.ncbi.nlm.nih.gov/pubmed/23915247
http://dx.doi.org/10.1186/1476-4598-12-88

Ejemplares similares