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Engineering Yeast Hexokinase 2 for Improved Tolerance Toward Xylose-Induced Inactivation

Hexokinase 2 (Hxk2p) from Saccharomyces cerevisiae is a bi-functional enzyme being both a catalyst and an important regulator in the glucose repression signal. In the presence of xylose Hxk2p is irreversibly inactivated through an autophosphorylation mechanism, affecting all functions. Consequently,...

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Detalles Bibliográficos
Autores principales:	Bergdahl, Basti, Sandström, Anders G., Borgström, Celina, Boonyawan, Tarinee, van Niel, Ed W. J., Gorwa-Grauslund, Marie F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765440/ https://www.ncbi.nlm.nih.gov/pubmed/24040384 http://dx.doi.org/10.1371/journal.pone.0075055

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