TLR-3 receptor activation protects the very immature brain from ischemic injury

BACKGROUND: We have shown that preconditioning by lipopolysaccharide (LPS) will result in 90% reduction in ischemic brain damage in P7 rats. This robust LPS neuroprotection was not observed in P3 or P5 pups (corresponding to human premature infant). LPS is a known Toll-like receptor 4 (TLR-4) ligand...

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Detalles Bibliográficos
Autores principales: Shi, Hui, Gabarin, Nadia, Hickey, Edward, Askalan, Rand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765441/
https://www.ncbi.nlm.nih.gov/pubmed/23965176
http://dx.doi.org/10.1186/1742-2094-10-104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765441/
https://www.ncbi.nlm.nih.gov/pubmed/23965176
http://dx.doi.org/10.1186/1742-2094-10-104

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