Sildenafil ameliorates biomarkers of genotoxicity in an experimental model of spontaneous atherosclerosis

BACKGROUND: It is well known that enhanced production of reactive oxygen species (ROS) leads to oxidative stress observed in atherosclerosis and that ROS can also cause damage in cellular macromolecules, including DNA. Considering previous report that sildenafil, an inhibitor of phosphodiesterase 5...

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Detalles Bibliográficos
Autores principales: Rodrigues, Bianca P, Campagnaro, Bianca P, Balarini, Camille M, Pereira, Thiago M C, Meyrelles, Silvana S, Vasquez, Elisardo C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766097/
https://www.ncbi.nlm.nih.gov/pubmed/23981672
http://dx.doi.org/10.1186/1476-511X-12-128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766097/
https://www.ncbi.nlm.nih.gov/pubmed/23981672
http://dx.doi.org/10.1186/1476-511X-12-128

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