Cargando…

Sildenafil ameliorates biomarkers of genotoxicity in an experimental model of spontaneous atherosclerosis

BACKGROUND: It is well known that enhanced production of reactive oxygen species (ROS) leads to oxidative stress observed in atherosclerosis and that ROS can also cause damage in cellular macromolecules, including DNA. Considering previous report that sildenafil, an inhibitor of phosphodiesterase 5...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodrigues, Bianca P, Campagnaro, Bianca P, Balarini, Camille M, Pereira, Thiago M C, Meyrelles, Silvana S, Vasquez, Elisardo C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766097/ https://www.ncbi.nlm.nih.gov/pubmed/23981672 http://dx.doi.org/10.1186/1476-511X-12-128

Ejemplares similares

Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension
por: Dias, Ananda T, et al.
Publicado: (2014)

Protective effect of sildenafil on the genotoxicity and cytotoxicity in apolipoprotein E-deficient mice bone marrow cells
por: Bernardes, Franciane P., et al.
Publicado: (2016)

Sildenafil restores endothelial function in the apolipoprotein E knockout mouse
por: Balarini, Camille M, et al.
Publicado: (2013)

Mononuclear cell therapy attenuates atherosclerosis in apoE KO mice
por: Porto, Marcella L, et al.
Publicado: (2011)

Cardiac-Autonomic Imbalance and Baroreflex Dysfunction in the Renovascular Angiotensin-Dependent Hypertensive Mouse
por: Campagnaro, Bianca P., et al.
Publicado: (2012)

Effects of Aging and Hypercholesterolemia on Oxidative Stress and DNA Damage in Bone Marrow Mononuclear Cells in Apolipoprotein E-deficient Mice
por: Tonini, Clarissa L., et al.
Publicado: (2013)

Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis
por: Jacinto, Thais A., et al.
Publicado: (2018)

Inhibition of phosphodiesterase 5 restores endothelial function in renovascular hypertension
por: Dias, Ananda T, et al.
Publicado: (2014)

Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy
por: Gomes, Isabele BS, et al.
Publicado: (2014)

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases
por: Pereira, Thiago M. C., et al.
Publicado: (2021)

Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice
por: Porto, Marcella L., et al.
Publicado: (2015)

DNA Damage and Augmented Oxidative Stress in Bone Marrow Mononuclear Cells from Angiotensin-Dependent Hypertensive Mice
por: Campagnaro, Bianca P., et al.
Publicado: (2013)

Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
por: Balarini, Camille M, et al.
Publicado: (2011)

Mononuclear cell therapy reverts cuff-induced thrombosis in apolipoprotein E-deficient mice
por: Lima, Leandro C F, et al.
Publicado: (2012)

Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases
por: Simoes, Giovana M. S., et al.
Publicado: (2013)

Oral P. gingivalis infection alters the vascular reactivity in healthy and spontaneously atherosclerotic mice
por: Pereira, Raquel B, et al.
Publicado: (2011)

The protective effects of oral low-dose quercetin on diabetic nephropathy in hypercholesterolemic mice
por: Gomes, Isabele B. S., et al.
Publicado: (2015)

Effects of Kefir on the Cardiac Autonomic Tones and Baroreflex Sensitivity in Spontaneously Hypertensive Rats
por: Klippel, Brunella F., et al.
Publicado: (2016)

Chronic administration of the probiotic kefir improves the endothelial function in spontaneously hypertensive rats
por: Friques, Andreia G. F., et al.
Publicado: (2015)

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects
por: Pereira, Thiago Melo Costa, et al.
Publicado: (2016)

Endothelial Dysfunction in the Apolipoprotein E-deficient Mouse: insights into the influence of diet, gender and aging
por: Meyrelles, Silvana S, et al.
Publicado: (2011)

Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse
por: Vasquez, Elisardo C, et al.
Publicado: (2012)

Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats
por: Freitas, Frederico F. C. T., et al.
Publicado: (2016)

Endogenous female sex hormones delay the development of renal dysfunction in apolipoprotein E-deficient mice
por: Carneiro, Sonila S, et al.
Publicado: (2014)

Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation
por: Ton, Alyne Mendonça Marques, et al.
Publicado: (2020)

Endothelial dysfunction of resistance vessels in female apolipoprotein E-deficient mice
por: Cola, Maine S, et al.
Publicado: (2010)

The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders
por: Queiroz, Sarha A. L., et al.
Publicado: (2022)

Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
por: Pereira, Thiago MC, et al.
Publicado: (2010)

Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks
por: Chisté, Layla Aparecida, et al.
Publicado: (2019)

Optimal Parameters of Laser Therapy to Improve Critical Calvarial Defects
por: Santos, Matheus AFM, et al.
Publicado: (2022)

Effects of tobacco smoking during pregnancy on oxidative stress in the umbilical cord and mononuclear blood cells of neonates
por: Rua, Ednildes de Almeida Olympio, et al.
Publicado: (2014)

Sildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice
por: Parchen, Candace M, et al.
Publicado: (2009)

Infrared laser therapy decreases systemic oxidative stress and inflammation in hypercholesterolemic mice with periodontitis
por: Ribeiro, Isadora Martins, et al.
Publicado: (2023)

Development and Evaluation of Virola oleifera Formulation for Cutaneous Wound Healing
por: Carvalho, Glaucimeire R., et al.
Publicado: (2022)

Sildenafil in endotoxin-induced pulmonary hypertension: an experimental study
por: Kemper, Daniella Aparecida Godoi, et al.
Publicado: (2021)

Resin from Virola oleifera Protects Against Radiocontrast-Induced Nephropathy in Mice
por: Bôa, Igor Santos Fonte, et al.
Publicado: (2015)

Sildenafil normalizes bowel transit in preclinical models of constipation
por: Sharman, Sarah K., et al.
Publicado: (2017)

Probiotics as Beneficial Dietary Supplements to Prevent and Treat Cardiovascular Diseases: Uncovering Their Impact on Oxidative Stress
por: Vasquez, Elisardo C., et al.
Publicado: (2019)

Gut Microbiota, Diet, and Chronic Diseases: The Role Played by Oxidative Stress
por: Vasquez, Elisardo C., et al.
Publicado: (2019)

Sildenafil Ameliorates Long Term Peripheral Neuropathy in Type II Diabetic Mice
por: Wang, Lei, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_586btnq2vk35310273murllurj