A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis

Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a neurodegenerative disorder with a poorly understood molecular mechanism. It is caused by mutations in Pantothenate Kinase, the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. Here, we developed a Drosophila model of PKAN (tim-fb...

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Detalles Bibliográficos
Autores principales: Pandey, Varun, Turm, Hagit, Bekenstein, Uriya, Shifman, Sagiv, Kadener, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766815/
https://www.ncbi.nlm.nih.gov/pubmed/24058333
http://dx.doi.org/10.3389/fncel.2013.00146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766815/
https://www.ncbi.nlm.nih.gov/pubmed/24058333
http://dx.doi.org/10.3389/fncel.2013.00146

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