NF-κB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action

The canonical IKKβ/NF-κB1 pathway has been well documented to promote insulin resistance; however, the noncanonical NIK/NF-κB2 pathway is poorly understood in obesity. Additionally, the contribution of counterregulatory hormones, particularly glucagon, to hyperglycemia in obesity remains unclear. He...

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Detalles Bibliográficos
Autores principales: Sheng, Liang, Zhou, Yingjiang, Chen, Zheng, Ren, Decheng, Cho, Kae Won, Jiang, Lin, Shen, Hong, Sasaki, Yoshiteru, Rui, Liangyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766969/
https://www.ncbi.nlm.nih.gov/pubmed/22581287
http://dx.doi.org/10.1038/nm.2756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766969/
https://www.ncbi.nlm.nih.gov/pubmed/22581287
http://dx.doi.org/10.1038/nm.2756

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