Topoisomerases facilitate transcription of long genes linked to autism

Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we found that topotecan, a Topoisomerase 1 (TOP1) inhibitor, dose-dependen...

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Detalles Bibliográficos
Autores principales: King, Ian F., Yandava, Chandri N., Mabb, Angela M., Hsiao, Jack S., Huang, Hsien-Sung, Pearson, Brandon L., Calabrese, J. Mauro, Starmer, Joshua, Parker, Joel S., Magnuson, Terry, Chamberlain, Stormy J., Philpot, Benjamin D., Zylka, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767287/
https://www.ncbi.nlm.nih.gov/pubmed/23995680
http://dx.doi.org/10.1038/nature12504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767287/
https://www.ncbi.nlm.nih.gov/pubmed/23995680
http://dx.doi.org/10.1038/nature12504

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