Cargando…
Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona
Vitamin D deficiency is an important problem in patients with chronic conditions including those with human immunodeficiency virus (HIV) infection. The aim of this cross-sectional study was to identify the prevalence and factors associated with vitamin D deficiency and hyperparathyroidism in HIV pat...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767361/ https://www.ncbi.nlm.nih.gov/pubmed/24052874 http://dx.doi.org/10.5402/2012/485307 |
_version_ | 1782283657174581248 |
---|---|
author | Lerma, Elisabet Molas, M. Ema Montero, M. Milagro Guelar, Ana González, Alicia Villar, Judith Diez, Adolf Knobel, Hernando |
author_facet | Lerma, Elisabet Molas, M. Ema Montero, M. Milagro Guelar, Ana González, Alicia Villar, Judith Diez, Adolf Knobel, Hernando |
author_sort | Lerma, Elisabet |
collection | PubMed |
description | Vitamin D deficiency is an important problem in patients with chronic conditions including those with human immunodeficiency virus (HIV) infection. The aim of this cross-sectional study was to identify the prevalence and factors associated with vitamin D deficiency and hyperparathyroidism in HIV patients attended in Barcelona. Cholecalciferol (25OH vitamin D3) and PTH levels were measured. Vitamin D insufficiency was defined as 25(OH) D < 20 ng/mL and deficiency as <12 ng/mL. Hyperparathyroidism was defined as PTH levels >65 pg/mL. Cases with chronic kidney failure, liver disease, treatments or conditions potentially affecting bone metabolism were excluded. Among the 566 patients included, 56.4% were exposed to tenofovir. Vitamin D insufficiency was found in 71.2% and 39.6% of those had deficiency. PTH was measured in 228 subjects, and 86 of them (37.7%) showed high levels. Adjusted predictors of vitamin D deficiency were nonwhite race and psychiatric comorbidity, while lipoatrophy was a protective factor. Independent risk factors of hyperparathyroidism were vitamin D < 12 ng/mL (OR: 2.14, CI 95%: 1.19–3.82, P: 0.01) and tenofovir exposure (OR: 3.55, CI 95%: 1.62–7.7, P: 0.002). High prevalence of vitamin deficiency and hyperparathyroidism was found in an area with high annual solar exposure. |
format | Online Article Text |
id | pubmed-3767361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-37673612013-09-19 Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona Lerma, Elisabet Molas, M. Ema Montero, M. Milagro Guelar, Ana González, Alicia Villar, Judith Diez, Adolf Knobel, Hernando ISRN AIDS Clinical Study Vitamin D deficiency is an important problem in patients with chronic conditions including those with human immunodeficiency virus (HIV) infection. The aim of this cross-sectional study was to identify the prevalence and factors associated with vitamin D deficiency and hyperparathyroidism in HIV patients attended in Barcelona. Cholecalciferol (25OH vitamin D3) and PTH levels were measured. Vitamin D insufficiency was defined as 25(OH) D < 20 ng/mL and deficiency as <12 ng/mL. Hyperparathyroidism was defined as PTH levels >65 pg/mL. Cases with chronic kidney failure, liver disease, treatments or conditions potentially affecting bone metabolism were excluded. Among the 566 patients included, 56.4% were exposed to tenofovir. Vitamin D insufficiency was found in 71.2% and 39.6% of those had deficiency. PTH was measured in 228 subjects, and 86 of them (37.7%) showed high levels. Adjusted predictors of vitamin D deficiency were nonwhite race and psychiatric comorbidity, while lipoatrophy was a protective factor. Independent risk factors of hyperparathyroidism were vitamin D < 12 ng/mL (OR: 2.14, CI 95%: 1.19–3.82, P: 0.01) and tenofovir exposure (OR: 3.55, CI 95%: 1.62–7.7, P: 0.002). High prevalence of vitamin deficiency and hyperparathyroidism was found in an area with high annual solar exposure. International Scholarly Research Network 2012-07-12 /pmc/articles/PMC3767361/ /pubmed/24052874 http://dx.doi.org/10.5402/2012/485307 Text en Copyright © 2012 Elisabet Lerma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Lerma, Elisabet Molas, M. Ema Montero, M. Milagro Guelar, Ana González, Alicia Villar, Judith Diez, Adolf Knobel, Hernando Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona |
title | Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona |
title_full | Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona |
title_fullStr | Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona |
title_full_unstemmed | Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona |
title_short | Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona |
title_sort | prevalence and factors associated with vitamin d deficiency and hyperparathyroidism in hiv-infected patients treated in barcelona |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767361/ https://www.ncbi.nlm.nih.gov/pubmed/24052874 http://dx.doi.org/10.5402/2012/485307 |
work_keys_str_mv | AT lermaelisabet prevalenceandfactorsassociatedwithvitaminddeficiencyandhyperparathyroidisminhivinfectedpatientstreatedinbarcelona AT molasmema prevalenceandfactorsassociatedwithvitaminddeficiencyandhyperparathyroidisminhivinfectedpatientstreatedinbarcelona AT monterommilagro prevalenceandfactorsassociatedwithvitaminddeficiencyandhyperparathyroidisminhivinfectedpatientstreatedinbarcelona AT guelarana prevalenceandfactorsassociatedwithvitaminddeficiencyandhyperparathyroidisminhivinfectedpatientstreatedinbarcelona AT gonzalezalicia prevalenceandfactorsassociatedwithvitaminddeficiencyandhyperparathyroidisminhivinfectedpatientstreatedinbarcelona AT villarjudith prevalenceandfactorsassociatedwithvitaminddeficiencyandhyperparathyroidisminhivinfectedpatientstreatedinbarcelona AT diezadolf prevalenceandfactorsassociatedwithvitaminddeficiencyandhyperparathyroidisminhivinfectedpatientstreatedinbarcelona AT knobelhernando prevalenceandfactorsassociatedwithvitaminddeficiencyandhyperparathyroidisminhivinfectedpatientstreatedinbarcelona |