Structural mechanism of cytosolic DNA sensing by cGAS

Cytosolic DNA arising from intracellular bacteria or viral infections is a powerful pathogen-associated molecular pattern (PAMP) that leads to innate immune host defense by the production of type I interferon and inflammatory cytokines. Recognition of cytosolic DNA by the recently discovered cyclic-...

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Detalles Bibliográficos
Autores principales: Civril, Filiz, Deimling, Tobias, de Oliveira Mann, Carina C., Ablasser, Andrea, Moldt, Manuela, Witte, Gregor, Hornung, Veit, Hopfner, Karl-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768140/
https://www.ncbi.nlm.nih.gov/pubmed/23722159
http://dx.doi.org/10.1038/nature12305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768140/
https://www.ncbi.nlm.nih.gov/pubmed/23722159
http://dx.doi.org/10.1038/nature12305

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