The Role of N-Glycosylation in Folding, Trafficking, and Functionality of Lysosomal Protein CLN5

CLN5 is a soluble lysosomal protein with unknown function. Mutations in CLN5 lead to neuronal ceroid lipofuscinosis, a group of inherited neurodegenerative disorders that mainly affect children. CLN5 has eight potential N-glycosylation sites based on the Asn-X-Thr/Ser consensus sequence. Through sit...

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Detalles Bibliográficos
Autores principales: Moharir, Akshay, Peck, Sun H., Budden, Theodore, Lee, Stella Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769244/
https://www.ncbi.nlm.nih.gov/pubmed/24058541
http://dx.doi.org/10.1371/journal.pone.0074299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769244/
https://www.ncbi.nlm.nih.gov/pubmed/24058541
http://dx.doi.org/10.1371/journal.pone.0074299

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