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The Role of N-Glycosylation in Folding, Trafficking, and Functionality of Lysosomal Protein CLN5
CLN5 is a soluble lysosomal protein with unknown function. Mutations in CLN5 lead to neuronal ceroid lipofuscinosis, a group of inherited neurodegenerative disorders that mainly affect children. CLN5 has eight potential N-glycosylation sites based on the Asn-X-Thr/Ser consensus sequence. Through sit...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769244/ https://www.ncbi.nlm.nih.gov/pubmed/24058541 http://dx.doi.org/10.1371/journal.pone.0074299 |