The Relationship between Functional Inhibition and Binding for K(Ca)2 Channel Blockers

Small conductance calcium-activated potassium channels (K(Ca)2.1,2.2,2.3) are blocked with high affinity by both peptide toxins (e.g. apamin) and small molecule blockers (e.g. UCL 1848). In electrophysiological experiments, apamin shows subtype selectivity with IC(50)s of ∼100 pM and ∼1 nM for block...

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Detalles Bibliográficos
Autores principales: Benton, David Charles Hammond, Garbarg, Monique, Moss, Guy William John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769273/
https://www.ncbi.nlm.nih.gov/pubmed/24039913
http://dx.doi.org/10.1371/journal.pone.0073328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769273/
https://www.ncbi.nlm.nih.gov/pubmed/24039913
http://dx.doi.org/10.1371/journal.pone.0073328

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