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The Relationship between Functional Inhibition and Binding for K(Ca)2 Channel Blockers
Small conductance calcium-activated potassium channels (K(Ca)2.1,2.2,2.3) are blocked with high affinity by both peptide toxins (e.g. apamin) and small molecule blockers (e.g. UCL 1848). In electrophysiological experiments, apamin shows subtype selectivity with IC(50)s of ∼100 pM and ∼1 nM for block...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769273/ https://www.ncbi.nlm.nih.gov/pubmed/24039913 http://dx.doi.org/10.1371/journal.pone.0073328 |