MLL Becomes Functional through Intra-Molecular Interaction Not by Proteolytic Processing

The mixed lineage leukemia (MLL) protein is an epigenetic transcriptional regulator that controls proliferative expansion of immature hematopoietic progenitors, whose aberrant activation triggers leukemogenesis. A mature MLL protein is produced by formation of an intra-molecular complex and proteoly...

Descripción completa

Detalles Bibliográficos
Autores principales: Yokoyama, Akihiko, Ficara, Francesca, Murphy, Mark J., Meisel, Christian, Hatanaka, Chikako, Kitabayashi, Issay, Cleary, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769346/
https://www.ncbi.nlm.nih.gov/pubmed/24040009
http://dx.doi.org/10.1371/journal.pone.0073649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769346/
https://www.ncbi.nlm.nih.gov/pubmed/24040009
http://dx.doi.org/10.1371/journal.pone.0073649

Ejemplares similares