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MLL Becomes Functional through Intra-Molecular Interaction Not by Proteolytic Processing

The mixed lineage leukemia (MLL) protein is an epigenetic transcriptional regulator that controls proliferative expansion of immature hematopoietic progenitors, whose aberrant activation triggers leukemogenesis. A mature MLL protein is produced by formation of an intra-molecular complex and proteoly...

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Detalles Bibliográficos
Autores principales:	Yokoyama, Akihiko, Ficara, Francesca, Murphy, Mark J., Meisel, Christian, Hatanaka, Chikako, Kitabayashi, Issay, Cleary, Michael L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769346/ https://www.ncbi.nlm.nih.gov/pubmed/24040009 http://dx.doi.org/10.1371/journal.pone.0073649

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