Rap1 GTPase Activation and Barrier Enhancement in RPE Inhibits Choroidal Neovascularization In Vivo

Loss of barrier integrity precedes the development of pathologies such as metastasis, inflammatory disorders, and blood-retinal barrier breakdown present in neovascular age-related macular degeneration. Rap1 GTPase is involved in regulating both endothelial and epithelial cell junctions; the specifi...

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Detalles Bibliográficos
Autores principales: Wittchen, Erika S., Nishimura, Eiichi, McCloskey, Manabu, Wang, Haibo, Quilliam, Lawrence A., Chrzanowska-Wodnicka, Magdalena, Hartnett, M. Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769400/
https://www.ncbi.nlm.nih.gov/pubmed/24039860
http://dx.doi.org/10.1371/journal.pone.0073070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769400/
https://www.ncbi.nlm.nih.gov/pubmed/24039860
http://dx.doi.org/10.1371/journal.pone.0073070

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