The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells

Poly(ADP-ribose) polymerase 1 (PARP1) is an important component of the base excision repair (BER) pathway as well as a regulator of homologous recombination (HR) and non-homologous end-joining (NHEJ). Previous studies have demonstrated that treatment of HR-deficient cells with PARP inhibitors result...

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Detalles Bibliográficos
Autores principales: De Lorenzo, Silvana B., Patel, Anand G., Hurley, Rachel M., Kaufmann, Scott H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769628/
https://www.ncbi.nlm.nih.gov/pubmed/24062981
http://dx.doi.org/10.3389/fonc.2013.00228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769628/
https://www.ncbi.nlm.nih.gov/pubmed/24062981
http://dx.doi.org/10.3389/fonc.2013.00228

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