Prechemistry Nucleotide Selection Checkpoints in the Reaction Pathway of DNA Polymerase I and Roles of Glu710 and Tyr766

[Image: see text] The accuracy of high-fidelity DNA polymerases such as DNA polymerase I (Klenow fragment) is governed by conformational changes early in the reaction pathway that serve as fidelity checkpoints, identifying inappropriate template–nucleotide pairings. The fingers-closing transition (d...

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Detalles Bibliográficos
Autores principales: Bermek, Oya, Grindley, Nigel D. F., Joyce, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770053/
https://www.ncbi.nlm.nih.gov/pubmed/23937394
http://dx.doi.org/10.1021/bi400837k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770053/
https://www.ncbi.nlm.nih.gov/pubmed/23937394
http://dx.doi.org/10.1021/bi400837k

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