Mitochondrial DNA Instability in Cells Lacking Aconitase Correlates with Iron Citrate Toxicity

Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1Δ results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its mainte...

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Detalles Bibliográficos
Autores principales: Farooq, Muhammad A., Pracheil, Tammy M., Dong, Zhejun, Xiao, Fei, Liu, Zhengchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770056/
https://www.ncbi.nlm.nih.gov/pubmed/24066190
http://dx.doi.org/10.1155/2013/493536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770056/
https://www.ncbi.nlm.nih.gov/pubmed/24066190
http://dx.doi.org/10.1155/2013/493536

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