Cargando…

Mitochondrial DNA Instability in Cells Lacking Aconitase Correlates with Iron Citrate Toxicity

Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1Δ results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its mainte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farooq, Muhammad A., Pracheil, Tammy M., Dong, Zhejun, Xiao, Fei, Liu, Zhengchang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770056/ https://www.ncbi.nlm.nih.gov/pubmed/24066190 http://dx.doi.org/10.1155/2013/493536

Ejemplares similares

Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
por: Singh, Keshav K, et al.
Publicado: (2006)

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants
por: Esposito, Giovanni, et al.
Publicado: (2013)

Ubiquitin-Conjugating Enzymes Ubc1 and Ubc4 Mediate the Turnover of Hap4, a Master Regulator of Mitochondrial Biogenesis in Saccharomyces cerevisiae
por: Capps, Denise, et al.
Publicado: (2022)

Biochemical elucidation of citrate accumulation in Synechocystis sp. PCC 6803 via kinetic analysis of aconitase
por: Nishii, Maki, et al.
Publicado: (2021)

Adenosine Triphosphate (ATP) Is a Candidate Signaling Molecule in the Mitochondria-to-Nucleus Retrograde Response Pathway
por: Zhang, Feng, et al.
Publicado: (2013)

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
por: Ternette, Nicola, et al.
Publicado: (2013)

Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
por: Mirhadi, Shideh, et al.
Publicado: (2023)

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response
por: Kim, Eunah, et al.
Publicado: (2023)

The Iron Maiden. Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis
por: Hognon, Cécilia, et al.
Publicado: (2021)

Aconitase: To Be or not to Be Inside Plant Glyoxysomes, That Is the Question
por: De Bellis, Luigi, et al.
Publicado: (2020)

Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H(2)O(2)-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures
por: Cantu, David, et al.
Publicado: (2009)

Crystal structures of aconitase X enzymes from bacteria and archaea provide insights into the molecular evolution of the aconitase superfamily
por: Watanabe, Seiya, et al.
Publicado: (2021)

Nitric Oxide Improves the Tolerance of Pleurotus ostreatus to Heat Stress by Inhibiting Mitochondrial Aconitase
por: Hou, Ludan, et al.
Publicado: (2020)

GWAS on multiple traits identifies mitochondrial ACONITASE3 as important for acclimation to submergence stress
por: Meng, Xiangxiang, et al.
Publicado: (2022)

Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency
por: Abela, Lucia, et al.
Publicado: (2017)

ACONITASE 3 is part of theANAC017 transcription factor-dependent mitochondrial dysfunction response
por: Pascual, Jesús, et al.
Publicado: (2021)

Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment
por: Goncalves, Sergio, et al.
Publicado: (2008)

Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD
por: Yoon, Nam Soo, et al.
Publicado: (2010)

Studying Acetylation of Aconitase Isozymes by Genetic Code Expansion
por: Araujo, Jessica, et al.
Publicado: (2022)

Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling
por: Talbot, Anne-Laure, et al.
Publicado: (2011)

Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation
por: Xue, Ya‐Nan, et al.
Publicado: (2019)

Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling
por: You, Xin, et al.
Publicado: (2021)

Mitochondrial Aconitase Enzymatic Activity: A Potential Long-Term Survival Biomarker in the Blood of ALS Patients
por: González-Mingot, Cristina, et al.
Publicado: (2023)

Effect of Salt Stress on the Expression and Promoter Methylation of the Genes Encoding the Mitochondrial and Cytosolic Forms of Aconitase and Fumarase in Maize
por: Eprintsev, Alexander T., et al.
Publicado: (2021)

Metabolic and Environmental Conditions Determine Nuclear Genomic Instability in Budding Yeast Lacking Mitochondrial DNA
por: Dirick, Léon, et al.
Publicado: (2013)

The iron-sensing aconitase B binds its own mRNA to prevent sRNA-induced mRNA cleavage
por: Benjamin, Julie-Anna M., et al.
Publicado: (2014)

Enhanced cardiac fatty acid utilization induced by high dietary fat: a potential regulatory role for mitochondrial aconitase
por: Fernandes, Jolyn, et al.
Publicado: (2012)

Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats
por: Liu, Run-Zhe, et al.
Publicado: (2022)

Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70)
por: Ben-Menachem, Reut, et al.
Publicado: (2018)

Molecular Evolution and Expression Divergence of the Aconitase (ACO) Gene Family in Land Plants
por: Wang, Yi-Ming, et al.
Publicado: (2016)

A prospective study on serum citrate levels and clinical correlations in patients receiving regional citrate anticoagulation
por: To, Harmony H M, et al.
Publicado: (2022)

The Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimer’s Disease
por: Chhimpa, Neeraj, et al.
Publicado: (2023)

Mitochondrial aconitase 1 regulates age‐related memory impairment via autophagy/mitophagy‐mediated neural plasticity in middle‐aged flies
por: Cho, Yun‐Ho, et al.
Publicado: (2021)

Metformin—clomiphene citrate vs. clomiphene citrate alone: Polycystic ovarian syndrome
por: Ayaz, Aqueela, et al.
Publicado: (2013)

Aconitase B Is Required for Optimal Growth of Xanthomonas campestris pv. vesicatoria in Pepper Plants
por: Kirchberg, Janine, et al.
Publicado: (2012)

Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase
por: Watanabe, Seiya, et al.
Publicado: (2016)

Transition Zone1 Negatively Regulates Arabidopsis Aluminum Resistance Through Interaction With Aconitases
por: Liu, Jiajia, et al.
Publicado: (2022)

Mitochondrial DNA Instability in Mammalian Cells
por: Carvalho, Gustavo, et al.
Publicado: (2022)

The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis
por: Catalina-Rodriguez, Olga, et al.
Publicado: (2012)

Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response
por: Ciccarone, Fabio, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qs56ef516b78taech6avs5rfe7