A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice

Deregulated Rho GTPases Rac1 and Cdc42 have been discovered in various tumors, including prostate and Rac protein expression significantly increases in prostate cancer. The Rac and Cdc42 pathways promote the uncontrolled proliferation, invasion and metastatic properties of human cancer cells. We syn...

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Detalles Bibliográficos
Autores principales: Zins, Karin, Lucas, Trevor, Reichl, Patrick, Abraham, Dietmar, Aharinejad, Seyedhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770583/
https://www.ncbi.nlm.nih.gov/pubmed/24040362
http://dx.doi.org/10.1371/journal.pone.0074924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770583/
https://www.ncbi.nlm.nih.gov/pubmed/24040362
http://dx.doi.org/10.1371/journal.pone.0074924

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