Striatal Pre-Enkephalin Overexpression Improves Huntington’s Disease Symptoms in the R6/2 Mouse Model of Huntington’s Disease

The reduction of pre-enkephalin (pENK) mRNA expression might be an early sign of striatal neuronal dysfunction in Huntington’s disease (HD), due to mutated huntingtin protein. Indeed, striatopallidal (pENK-containing) neurodegeneration occurs at earlier stage of the disease, compare to the loss of s...

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Detalles Bibliográficos
Autores principales: Bissonnette, Stéphanie, Vaillancourt, Mylène, Hébert, Sébastien S., Drolet, Guy, Samadi, Pershia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770591/
https://www.ncbi.nlm.nih.gov/pubmed/24040390
http://dx.doi.org/10.1371/journal.pone.0075099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770591/
https://www.ncbi.nlm.nih.gov/pubmed/24040390
http://dx.doi.org/10.1371/journal.pone.0075099

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