Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications

SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation. We have determined the structure of the complex between first CD2AP SH3 domain and ubiquitin and performed a structural and m...

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Detalles Bibliográficos
Autores principales: Ortega Roldan, Jose L., Casares, Salvador, Ringkjøbing Jensen, Malene, Cárdenes, Nayra, Bravo, Jerónimo, Blackledge, Martin, Azuaga, Ana I., van Nuland, Nico A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770644/
https://www.ncbi.nlm.nih.gov/pubmed/24039852
http://dx.doi.org/10.1371/journal.pone.0073018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770644/
https://www.ncbi.nlm.nih.gov/pubmed/24039852
http://dx.doi.org/10.1371/journal.pone.0073018

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