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Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications
SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation. We have determined the structure of the complex between first CD2AP SH3 domain and ubiquitin and performed a structural and m...
Autores principales: | Ortega Roldan, Jose L., Casares, Salvador, Ringkjøbing Jensen, Malene, Cárdenes, Nayra, Bravo, Jerónimo, Blackledge, Martin, Azuaga, Ana I., van Nuland, Nico A. J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770644/ https://www.ncbi.nlm.nih.gov/pubmed/24039852 http://dx.doi.org/10.1371/journal.pone.0073018 |
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