Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation

HTRA1 is a member of the High Temperature Requirement (HTRA1) family of serine proteases, which play a role in several biological and pathological processes. In part, HTRA1 regulation occurs by inhibiting the TGF-β signaling pathway, however the mechanism of inhibition has not been fully defined. Pr...

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Detalles Bibliográficos
Autores principales: Graham, Julie R., Chamberland, Angela, Lin, Qingcong, Li, X. Jian, Dai, David, Zeng, Weilan, Ryan, Mark S., Rivera-Bermúdez, Moisés A., Flannery, Carl R., Yang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770692/
https://www.ncbi.nlm.nih.gov/pubmed/24040176
http://dx.doi.org/10.1371/journal.pone.0074094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770692/
https://www.ncbi.nlm.nih.gov/pubmed/24040176
http://dx.doi.org/10.1371/journal.pone.0074094

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