Inhibition of Plk1 and Cyclin B1 Expression Results in Panobinostat-Induced G(2) Delay and Mitotic Defects

The development of clinically useful histone deacetylase inhibitors has expanded greatly. In a preclinical study, we showed that panobinostat (LBH589) inhibits cell cycle progression of human head and neck squamous cell carcinoma (HNSCC) cell lines at G(2)/M and an associated decrease in expression...

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Detalles Bibliográficos
Autores principales: Prystowsky, Michael, Feeney, Katherine, Kawachi, Nicole, Montagna, Cristina, Willmott, Michelle, Wasson, Christopher, Antkowiak, Maciej, Loudig, Olivier, Parish, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770962/
https://www.ncbi.nlm.nih.gov/pubmed/24026482
http://dx.doi.org/10.1038/srep02640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770962/
https://www.ncbi.nlm.nih.gov/pubmed/24026482
http://dx.doi.org/10.1038/srep02640

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