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Inhibition of Plk1 and Cyclin B1 Expression Results in Panobinostat-Induced G(2) Delay and Mitotic Defects
The development of clinically useful histone deacetylase inhibitors has expanded greatly. In a preclinical study, we showed that panobinostat (LBH589) inhibits cell cycle progression of human head and neck squamous cell carcinoma (HNSCC) cell lines at G(2)/M and an associated decrease in expression...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770962/ https://www.ncbi.nlm.nih.gov/pubmed/24026482 http://dx.doi.org/10.1038/srep02640 |