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Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
A genipin-cross-linked chitosan/graphene oxide (GCS/GO) composite film was prepared using a solution casting method. Fourier transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy of the composite films showed that the interactions between the CS and oxygen-containing groups of GO r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771746/ https://www.ncbi.nlm.nih.gov/pubmed/24039424 http://dx.doi.org/10.2147/IJN.S51203 |
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author | Li, Jianhua Ren, Na Qiu, Jichuan Mou, Xiaoning Liu, Hong |
author_facet | Li, Jianhua Ren, Na Qiu, Jichuan Mou, Xiaoning Liu, Hong |
author_sort | Li, Jianhua |
collection | PubMed |
description | A genipin-cross-linked chitosan/graphene oxide (GCS/GO) composite film was prepared using a solution casting method. Fourier transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy of the composite films showed that the interactions between the CS and oxygen-containing groups of GO resulted in good dispersion of the GO sheets in the CS network. The addition of GO decreased the expansion ratio of the composite films in physiological conditions and increased the resistance to degradation by lysozymes in vitro. As well, the tensile strength values of the GCS/GO films were significantly increased with the increasing load of GO. Moreover, the GCS/GO composite film also maintained the intrinsic fluorescence of GCS. The in vitro cell study results revealed that the composite films were suitable for the proliferation and adhesion of mouse preosteoblast (MC3T3-E1) cells. The GCS/GO biocomposite films might have a potential use in tissue engineering, bioimaging, and drug delivery. |
format | Online Article Text |
id | pubmed-3771746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-37717462013-09-13 Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility Li, Jianhua Ren, Na Qiu, Jichuan Mou, Xiaoning Liu, Hong Int J Nanomedicine Original Research A genipin-cross-linked chitosan/graphene oxide (GCS/GO) composite film was prepared using a solution casting method. Fourier transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy of the composite films showed that the interactions between the CS and oxygen-containing groups of GO resulted in good dispersion of the GO sheets in the CS network. The addition of GO decreased the expansion ratio of the composite films in physiological conditions and increased the resistance to degradation by lysozymes in vitro. As well, the tensile strength values of the GCS/GO films were significantly increased with the increasing load of GO. Moreover, the GCS/GO composite film also maintained the intrinsic fluorescence of GCS. The in vitro cell study results revealed that the composite films were suitable for the proliferation and adhesion of mouse preosteoblast (MC3T3-E1) cells. The GCS/GO biocomposite films might have a potential use in tissue engineering, bioimaging, and drug delivery. Dove Medical Press 2013 2013-09-02 /pmc/articles/PMC3771746/ /pubmed/24039424 http://dx.doi.org/10.2147/IJN.S51203 Text en © 2013 Li et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed. |
spellingShingle | Original Research Li, Jianhua Ren, Na Qiu, Jichuan Mou, Xiaoning Liu, Hong Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility |
title | Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility |
title_full | Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility |
title_fullStr | Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility |
title_full_unstemmed | Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility |
title_short | Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility |
title_sort | graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771746/ https://www.ncbi.nlm.nih.gov/pubmed/24039424 http://dx.doi.org/10.2147/IJN.S51203 |
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