Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Somatic chromosomal deletions in cancer are thought to indicate the location of tumor suppressor genes, whereby complete loss of gene function occurs through biallelic deletion, point mutation, or epigenetic silencing, thus fulfilling Knudson's two-hit hypothesis.(1) In many recurrent deletions...

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Detalles Bibliográficos
Autores principales: Ebert, Benjamin L., Pretz, Jennifer, Bosco, Jocelyn, Chang, Cindy Y., Tamayo, Pablo, Galili, Naomi, Raza, Azra, Root, David E., Attar, Eyal, Ellis, Steven R., Golub, Todd R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771855/
https://www.ncbi.nlm.nih.gov/pubmed/18202658
http://dx.doi.org/10.1038/nature06494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771855/
https://www.ncbi.nlm.nih.gov/pubmed/18202658
http://dx.doi.org/10.1038/nature06494

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