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Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
Somatic chromosomal deletions in cancer are thought to indicate the location of tumor suppressor genes, whereby complete loss of gene function occurs through biallelic deletion, point mutation, or epigenetic silencing, thus fulfilling Knudson's two-hit hypothesis.(1) In many recurrent deletions...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771855/ https://www.ncbi.nlm.nih.gov/pubmed/18202658 http://dx.doi.org/10.1038/nature06494 |