Desensitization by Progressive Up-Titration Prevents First-Dose Effects on the Heart: Guinea Pig Study with Ponesimod, a Selective S1P(1) Receptor Modulator

Ponesimod, a selective S1P(1) receptor modulator, reduces the blood lymphocyte count in all tested species by preventing egress of T and B cells from thymus and peripheral lymphoid organs. In addition, ponesimod transiently affects heart rate and atrioventricular (AV) conduction in humans, effects n...

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Detalles Bibliográficos
Autores principales: Rey, Markus, Hess, Patrick, Clozel, Martine, Delahaye, Stéphane, Gatfield, John, Nayler, Oliver, Steiner, Beat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771878/
https://www.ncbi.nlm.nih.gov/pubmed/24069292
http://dx.doi.org/10.1371/journal.pone.0074285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771878/
https://www.ncbi.nlm.nih.gov/pubmed/24069292
http://dx.doi.org/10.1371/journal.pone.0074285

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