Genome-Wide Mouse Mutagenesis Reveals CD45-Mediated T Cell Function as Critical in Protective Immunity to HSV-1

Herpes simplex encephalitis (HSE) is a lethal neurological disease resulting from infection with Herpes Simplex Virus 1 (HSV-1). Loss-of-function mutations in the UNC93B1, TLR3, TRIF, TRAF3, and TBK1 genes have been associated with a human genetic predisposition to HSE, demonstrating the UNC93B-TLR3...

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Detalles Bibliográficos
Autores principales: Caignard, Grégory, Leiva-Torres, Gabriel A., Leney-Greene, Michael, Charbonneau, Benoit, Dumaine, Anne, Fodil-Cornu, Nassima, Pyzik, Michal, Cingolani, Pablo, Schwartzentruber, Jeremy, Dupaul-Chicoine, Jeremy, Guo, Huaijian, Saleh, Maya, Veillette, André, Lathrop, Marc, Blanchette, Mathieu, Majewski, Jacek, Pearson, Angela, Vidal, Silvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771889/
https://www.ncbi.nlm.nih.gov/pubmed/24068938
http://dx.doi.org/10.1371/journal.ppat.1003637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771889/
https://www.ncbi.nlm.nih.gov/pubmed/24068938
http://dx.doi.org/10.1371/journal.ppat.1003637

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