The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation

Photoreceptor-specific nuclear receptor (PNR, NR2E3) is a key transcriptional regulator of human photoreceptor differentiation and maintenance. Mutations in the NR2E3-encoding gene cause various retinal degenerations, including Enhanced S-cone syndrome, retinitis pigmentosa, and Goldman-Favre diseas...

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Detalles Bibliográficos
Autores principales: Tan, M. H. Eileen, Zhou, X. Edward, Soon, Fen-Fen, Li, Xiaodan, Li, Jun, Yong, Eu-Leong, Melcher, Karsten, Xu, H. Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771917/
https://www.ncbi.nlm.nih.gov/pubmed/24069298
http://dx.doi.org/10.1371/journal.pone.0074359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771917/
https://www.ncbi.nlm.nih.gov/pubmed/24069298
http://dx.doi.org/10.1371/journal.pone.0074359

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