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Striatal Infusion of Glial Conditioned Medium Diminishes Huntingtin Pathology in R6/1 Mice

Huntington's disease is a neurodegenerative disorder caused by an expansion of CAG repeats in the huntingtin gene which produces widespread neuronal and glial pathology. We here investigated the possible therapeutic role of glia or glial products in Huntington's disease using striatal glia...

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Detalles Bibliográficos
Autores principales: Perucho, Juan, Casarejos, Maria José, Gómez, Ana, Ruíz, Carolina, Fernández-Estevez, Maria Ángeles, Muñoz, Maria Paz, de Yébenes, Justo García, Mena, Maria Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771920/
https://www.ncbi.nlm.nih.gov/pubmed/24069174
http://dx.doi.org/10.1371/journal.pone.0073120