Cargando…

Striatal Infusion of Glial Conditioned Medium Diminishes Huntingtin Pathology in R6/1 Mice

Huntington's disease is a neurodegenerative disorder caused by an expansion of CAG repeats in the huntingtin gene which produces widespread neuronal and glial pathology. We here investigated the possible therapeutic role of glia or glial products in Huntington's disease using striatal glia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Perucho, Juan, Casarejos, Maria José, Gómez, Ana, Ruíz, Carolina, Fernández-Estevez, Maria Ángeles, Muñoz, Maria Paz, de Yébenes, Justo García, Mena, Maria Ángeles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771920/ https://www.ncbi.nlm.nih.gov/pubmed/24069174 http://dx.doi.org/10.1371/journal.pone.0073120

Ejemplares similares

Protection by glia-conditioned medium in a cell model of Huntington disease
por: Ruiz, Carolina, et al.
Publicado: (2012)

Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington's Disease Patients Caused by Proteosome Inhibition
por: Fernandez-Estevez, Maria Angeles, et al.
Publicado: (2014)

Trehalose Improves Human Fibroblast Deficits in a New CHIP-Mutation Related Ataxia
por: Casarejos, Maria Jose, et al.
Publicado: (2014)

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin
por: Galvan, Laurie, et al.
Publicado: (2018)

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
por: Yao, Yuwei, et al.
Publicado: (2015)

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
por: Shin, Ji-Yeon, et al.
Publicado: (2005)

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice
por: Kovalenko, Marina, et al.
Publicado: (2012)

Dysregulated Striatal Neuronal Processing and Impaired Motor Behavior in Mice Lacking Huntingtin Interacting Protein 14 (HIP14)
por: Estrada-Sánchez, Ana María, et al.
Publicado: (2013)

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
por: Marchionini, Deanna M., et al.
Publicado: (2022)

Glial Cell Lineage Expression of Mutant Ataxin-1 and Huntingtin Induces Developmental and Late-Onset Neuronal Pathologies in Drosophila Models
por: Tamura, Takuya, et al.
Publicado: (2009)

Huntingtin Interacting Proteins and Pathological Implications
por: Liu, Li, et al.
Publicado: (2023)

Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes
por: Wakida, Nicole M., et al.
Publicado: (2022)

Phase Transition of Huntingtin: Factors and Pathological Relevance
por: Yang, Junsheng, et al.
Publicado: (2020)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin
por: Leitman, Julia, et al.
Publicado: (2014)

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models
por: Franich, Nicholas R., et al.
Publicado: (2018)

Mutant huntingtin enhances activation of dendritic Kv4 K(+) channels in striatal spiny projection neurons
por: Carrillo-Reid, Luis, et al.
Publicado: (2019)

Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit
por: Jaaro-Peled, Hanna, et al.
Publicado: (2022)

Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model
por: Pan, Yongcheng, et al.
Publicado: (2023)

Pyk2 Stabilizes Striatal Medium Spiny Neuron Structure and Striatal-Dependent Action
por: Gourley, Shannon L., et al.
Publicado: (2021)

Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies
por: Lima, Rafael R., et al.
Publicado: (2016)

Medium-Sized Cities Facing the Demographic Challenge in Spain’s Low-Density Regions through Citizen Participation Projects
por: Rodríguez-Domenech, María Ángeles
Publicado: (2022)

Estrogen/Huntingtin: a novel pathway involved in neuroprotection
por: Nuzzo, Maria Teresa, et al.
Publicado: (2016)

Optimal Balance of the Striatal Medium Spiny Neuron Network
por: Ponzi, Adam, et al.
Publicado: (2013)

Conditional targeting of medium spiny neurons in the striatal matrix
por: Reinius, Björn, et al.
Publicado: (2015)

Food image-induced brain activation is not diminished by insulin infusion
por: Belfort-DeAguiar, Renata, et al.
Publicado: (2016)

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II
por: Benchoua, Alexandra, et al.
Publicado: (2008)

Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons
por: Trushina, Eugenia, et al.
Publicado: (2009)

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease
por: Francelle, Laetitia, et al.
Publicado: (2015)

Extrasynaptic Neurotransmission in the Modulation of Brain Function. Focus on the Striatal Neuronal–Glial Networks
por: Fuxe, Kjell, et al.
Publicado: (2012)

The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade
por: Hickman, Richard A., et al.
Publicado: (2022)

Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins
por: Bonfanti, Silvia, et al.
Publicado: (2019)

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
por: Al-Ramahi, Ismael, et al.
Publicado: (2017)

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects
por: Faideau, Mathilde, et al.
Publicado: (2010)

Glial glucokinase expression in adult and post-natal development of the hypothalamic region
por: Millán, Carola, et al.
Publicado: (2010)

Targeted Genetic Reduction of Mutant Huntingtin Lessens Cardiac Pathology in the BACHD Mouse Model of Huntington's Disease
por: Park, Saemi, et al.
Publicado: (2021)

Huntingtin’s Function in Axonal Transport Is Conserved in Drosophila melanogaster
por: Zala, Diana, et al.
Publicado: (2013)

Huntingtin and the Synapse
por: Barron, Jessica C., et al.
Publicado: (2021)

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
por: Fodale, Valentina, et al.
Publicado: (2020)

Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA
por: Grondin, Richard, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3kpjp4424esgaifuh9f702ilg6