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JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

Intestinal barrier function is regulated by epithelial tight junctions (TJs), structures that control paracellular permeability. Junctional adhesion molecule-A (JAM-A) is a TJ-associated protein that regulates barrier; however, mechanisms linking JAM-A to epithelial permeability are poorly understoo...

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Detalles Bibliográficos
Autores principales: Monteiro, Ana C., Sumagin, Ronen, Rankin, Carl R., Leoni, Giovanna, Mina, Michael J., Reiter, Dirk M., Stehle, Thilo, Dermody, Terence S., Schaefer, Stacy A., Hall, Randy A., Nusrat, Asma, Parkos, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771947/
https://www.ncbi.nlm.nih.gov/pubmed/23885123
http://dx.doi.org/10.1091/mbc.E13-06-0298