Cargando…
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function
Intestinal barrier function is regulated by epithelial tight junctions (TJs), structures that control paracellular permeability. Junctional adhesion molecule-A (JAM-A) is a TJ-associated protein that regulates barrier; however, mechanisms linking JAM-A to epithelial permeability are poorly understoo...
Autores principales: | Monteiro, Ana C., Sumagin, Ronen, Rankin, Carl R., Leoni, Giovanna, Mina, Michael J., Reiter, Dirk M., Stehle, Thilo, Dermody, Terence S., Schaefer, Stacy A., Hall, Randy A., Nusrat, Asma, Parkos, Charles A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771947/ https://www.ncbi.nlm.nih.gov/pubmed/23885123 http://dx.doi.org/10.1091/mbc.E13-06-0298 |
Ejemplares similares
-
Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface
por: Monteiro, Ana C., et al.
Publicado: (2014) -
JAM-A regulates permeability and inflammation in the intestine in vivo
por: Laukoetter, Mike G., et al.
Publicado: (2007) -
Rap-afadin axis in control of Rho signaling and endothelial barrier recovery
por: Birukova, Anna A., et al.
Publicado: (2013) -
Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth
por: Hisata, Shu, et al.
Publicado: (2007) -
Activation of PKCβII by PMA Facilitates Enhanced Epithelial Wound Repair through Increased Cell Spreading and Migration
por: Sumagin, Ronen, et al.
Publicado: (2013)