The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium

The adult mammalian heart has limited capability for self-repair after myocardial infarction. Therefore, therapeutic strategies that improve post-infarct cardiac function are critically needed. The small molecule ICG-001 modulates Wnt signaling and increased the expression of genes beneficial for ca...

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Autores principales: Sasaki, Tomoyo, Hwang, Hyosook, Nguyen, Cu, Kloner, Robert A., Kahn, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771968/
https://www.ncbi.nlm.nih.gov/pubmed/24069374
http://dx.doi.org/10.1371/journal.pone.0075010
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author Sasaki, Tomoyo
Hwang, Hyosook
Nguyen, Cu
Kloner, Robert A.
Kahn, Michael
author_facet Sasaki, Tomoyo
Hwang, Hyosook
Nguyen, Cu
Kloner, Robert A.
Kahn, Michael
author_sort Sasaki, Tomoyo
collection PubMed
description The adult mammalian heart has limited capability for self-repair after myocardial infarction. Therefore, therapeutic strategies that improve post-infarct cardiac function are critically needed. The small molecule ICG-001 modulates Wnt signaling and increased the expression of genes beneficial for cardiac regeneration in epicardial cells. Lineage tracing experiments, demonstrated the importance of β-catenin/p300 mediated transcription for epicardial progenitor contribution to the myocardium. Female rats given ICG-001 for 10 days post-occlusion significantly improved ejection fraction by 8.4%, compared to controls (P<0.05). Taken together, Wnt modulation via β-catenin/CBP inhibition offers a promising therapeutic strategy towards restoration of myocardial tissues and an enhancement of cardiac functions following infarction.
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spelling pubmed-37719682013-09-25 The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium Sasaki, Tomoyo Hwang, Hyosook Nguyen, Cu Kloner, Robert A. Kahn, Michael PLoS One Research Article The adult mammalian heart has limited capability for self-repair after myocardial infarction. Therefore, therapeutic strategies that improve post-infarct cardiac function are critically needed. The small molecule ICG-001 modulates Wnt signaling and increased the expression of genes beneficial for cardiac regeneration in epicardial cells. Lineage tracing experiments, demonstrated the importance of β-catenin/p300 mediated transcription for epicardial progenitor contribution to the myocardium. Female rats given ICG-001 for 10 days post-occlusion significantly improved ejection fraction by 8.4%, compared to controls (P<0.05). Taken together, Wnt modulation via β-catenin/CBP inhibition offers a promising therapeutic strategy towards restoration of myocardial tissues and an enhancement of cardiac functions following infarction. Public Library of Science 2013-09-12 /pmc/articles/PMC3771968/ /pubmed/24069374 http://dx.doi.org/10.1371/journal.pone.0075010 Text en © 2013 Sasaki et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sasaki, Tomoyo
Hwang, Hyosook
Nguyen, Cu
Kloner, Robert A.
Kahn, Michael
The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
title The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
title_full The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
title_fullStr The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
title_full_unstemmed The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
title_short The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
title_sort small molecule wnt signaling modulator icg-001 improves contractile function in chronically infarcted rat myocardium
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771968/
https://www.ncbi.nlm.nih.gov/pubmed/24069374
http://dx.doi.org/10.1371/journal.pone.0075010
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