Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway

Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases. Since many of the deleterious effects of glucose have been attributed to its metabolite met...

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Detalles Bibliográficos
Autores principales: Hadas, Karin, Randriamboavonjy, Voahanginirina, Elgheznawy, Amro, Mann, Alexander, Fleming, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772821/
https://www.ncbi.nlm.nih.gov/pubmed/24058557
http://dx.doi.org/10.1371/journal.pone.0074401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772821/
https://www.ncbi.nlm.nih.gov/pubmed/24058557
http://dx.doi.org/10.1371/journal.pone.0074401

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