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Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway
Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases. Since many of the deleterious effects of glucose have been attributed to its metabolite met...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772821/ https://www.ncbi.nlm.nih.gov/pubmed/24058557 http://dx.doi.org/10.1371/journal.pone.0074401 |