Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases

The CXCR4/CXCL12 axis plays a role in cancer metastases, stem cell mobilization and chemosensitization. Proof of concept for efficient CXCR4 inhibition has been demonstrated in stem cell mobilization prior to autologous transplantation in hematological malignancies. Nevertheless CXCR4 inhibitors sui...

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Detalles Bibliográficos
Autores principales: Portella, Luigi, Vitale, Rosamaria, De Luca, Stefania, D’Alterio, Crescenzo, Ieranò, Caterina, Napolitano, Maria, Riccio, Anna, Polimeno, Maria Neve, Monfregola, Luca, Barbieri, Antonio, Luciano, Antonio, Ciarmiello, Andrea, Arra, Claudio, Castello, Giuseppe, Amodeo, Pietro, Scala, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772838/
https://www.ncbi.nlm.nih.gov/pubmed/24058588
http://dx.doi.org/10.1371/journal.pone.0074548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772838/
https://www.ncbi.nlm.nih.gov/pubmed/24058588
http://dx.doi.org/10.1371/journal.pone.0074548

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