Acquired MET Expression Confers Resistance to EGFR Inhibition In a Mouse Model of Glioblastoma Multiforme

Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type EGFR and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient features of this deadly cancer. Surprisingly, targeted inhibition of EGFR has been clinically disappointing, d...

Descripción completa

Detalles Bibliográficos
Autores principales: Jun, Hyun Jung, Acquaviva, Jaime, Chi, Dorcas, Lessard, Julie, Zhu, Haihao, Woolfenden, Steve, Bronson, Roderick T., Pfannl, Rolf, White, Forest, Housman, David E., Iyer, Lakshmanan, Whittaker, Charles A., Boskovitz, Abraham, Raval, Ami, Charest, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774279/
https://www.ncbi.nlm.nih.gov/pubmed/22020333
http://dx.doi.org/10.1038/onc.2011.474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774279/
https://www.ncbi.nlm.nih.gov/pubmed/22020333
http://dx.doi.org/10.1038/onc.2011.474

Ejemplares similares