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Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation

We investigate the effects of adding periodic stimulation to a generic, conductance-based neuron model that includes ion concentration dynamics of sodium and potassium. Under conditions of high extracellular potassium, the model exhibits repeating, spontaneous, seizure-like bursting events associate...

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Detalles Bibliográficos
Autores principales: Owen, Jeremy A., Barreto, Ernest, Cressman, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774776/
https://www.ncbi.nlm.nih.gov/pubmed/24066075
http://dx.doi.org/10.1371/journal.pone.0073820
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author Owen, Jeremy A.
Barreto, Ernest
Cressman, John R.
author_facet Owen, Jeremy A.
Barreto, Ernest
Cressman, John R.
author_sort Owen, Jeremy A.
collection PubMed
description We investigate the effects of adding periodic stimulation to a generic, conductance-based neuron model that includes ion concentration dynamics of sodium and potassium. Under conditions of high extracellular potassium, the model exhibits repeating, spontaneous, seizure-like bursting events associated with slow modulation of the ion concentrations local to the neuron. We show that for a range of parameter values, depolarizing and hyperpolarizing periodic stimulation pulses (including frequencies lower than 4 Hz) can stop the spontaneous bursting by interacting with the ion concentration dynamics. Stimulation can also control the magnitude of evoked responses to modeled physiological inputs. We develop an understanding of the nonlinear dynamics of this system by a timescale separation procedure that identifies effective nullclines in the ion concentration parameter space. Our results suggest that the manipulation of ion concentration dynamics via external or endogenous stimulation may play an important role in neuronal excitability, seizure dynamics, and control.
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spelling pubmed-37747762013-09-24 Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation Owen, Jeremy A. Barreto, Ernest Cressman, John R. PLoS One Research Article We investigate the effects of adding periodic stimulation to a generic, conductance-based neuron model that includes ion concentration dynamics of sodium and potassium. Under conditions of high extracellular potassium, the model exhibits repeating, spontaneous, seizure-like bursting events associated with slow modulation of the ion concentrations local to the neuron. We show that for a range of parameter values, depolarizing and hyperpolarizing periodic stimulation pulses (including frequencies lower than 4 Hz) can stop the spontaneous bursting by interacting with the ion concentration dynamics. Stimulation can also control the magnitude of evoked responses to modeled physiological inputs. We develop an understanding of the nonlinear dynamics of this system by a timescale separation procedure that identifies effective nullclines in the ion concentration parameter space. Our results suggest that the manipulation of ion concentration dynamics via external or endogenous stimulation may play an important role in neuronal excitability, seizure dynamics, and control. Public Library of Science 2013-09-16 /pmc/articles/PMC3774776/ /pubmed/24066075 http://dx.doi.org/10.1371/journal.pone.0073820 Text en © 2013 Cressman et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Owen, Jeremy A.
Barreto, Ernest
Cressman, John R.
Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation
title Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation
title_full Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation
title_fullStr Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation
title_full_unstemmed Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation
title_short Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation
title_sort controlling seizure-like events by perturbing ion concentration dynamics with periodic stimulation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774776/
https://www.ncbi.nlm.nih.gov/pubmed/24066075
http://dx.doi.org/10.1371/journal.pone.0073820
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