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Genome-wide shRNA screening to identify factors mediating Gata6 repression in mouse embryonic stem cells

The use of whole-genome pooled shRNA libraries in loss-of-function screening in tissue culture models provides an effective means to identify novel factors acting in pathways of interest. Embryonic stem cells (ESCs) offer a unique opportunity to study processes involved in stem cell pluripotency and...

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Detalles Bibliográficos
Autores principales: Cooper, Sarah, Brockdorff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Company of Biologists 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775421/
https://www.ncbi.nlm.nih.gov/pubmed/24046324
http://dx.doi.org/10.1242/dev.094615