Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo

IL (interleukin)-8 [CXCL8 (CXC chemokine ligand 8)] exerts its role in inflammation by triggering neutrophils via its specific GPCRs (G-protein-coupled receptors), CXCR1 (CXC chemokine receptor 1) and CXCR2, for which additional binding to endothelial HS-GAGs (heparan sulphate-glycosaminoglycans) is...

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Detalles Bibliográficos
Autores principales: Falsone, Angelika, Wabitsch, Veronica, Geretti, Elena, Potzinger, Heide, Gerlza, Tanja, Robinson, James, Adage, Tiziana, Teixeira, Mauro M., Kungl, Andreas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775513/
https://www.ncbi.nlm.nih.gov/pubmed/23919527
http://dx.doi.org/10.1042/BSR20130069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775513/
https://www.ncbi.nlm.nih.gov/pubmed/23919527
http://dx.doi.org/10.1042/BSR20130069

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