Cargando…

Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo

IL (interleukin)-8 [CXCL8 (CXC chemokine ligand 8)] exerts its role in inflammation by triggering neutrophils via its specific GPCRs (G-protein-coupled receptors), CXCR1 (CXC chemokine receptor 1) and CXCR2, for which additional binding to endothelial HS-GAGs (heparan sulphate-glycosaminoglycans) is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Falsone, Angelika, Wabitsch, Veronica, Geretti, Elena, Potzinger, Heide, Gerlza, Tanja, Robinson, James, Adage, Tiziana, Teixeira, Mauro M., Kungl, Andreas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2013
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775513/ https://www.ncbi.nlm.nih.gov/pubmed/23919527 http://dx.doi.org/10.1042/BSR20130069

Ejemplares similares

A Combinatorial Approach to Biophysically Characterise Chemokine-Glycan Binding Affinities for Drug Development
por: Gerlza, Tanja, et al.
Publicado: (2014)

Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding()
por: Roblek, Marko, et al.
Publicado: (2016)

Cytokines and Chemokines in SARS-CoV-2 Infections—Therapeutic Strategies Targeting Cytokine Storm
por: Pum, Alexandra, et al.
Publicado: (2021)

Isolation and Characterization of Heparan Sulfate from Human Lung Tissues †
por: Derler, Rupert, et al.
Publicado: (2021)

The Role of Heparan Sulfate in CCL26-Induced Eosinophil Chemotaxis
por: Pum, Alexandra, et al.
Publicado: (2022)

Enoxaparin and Pentosan Polysulfate Bind to the SARS-CoV-2 Spike Protein and Human ACE2 Receptor, Inhibiting Vero Cell Infection
por: Ennemoser, Maria, et al.
Publicado: (2021)

Glycosaminoglycan-Mediated Downstream Signaling of CXCL8 Binding to Endothelial Cells
por: Derler, Rupert, et al.
Publicado: (2017)

CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions
por: Vanheule, Vincent, et al.
Publicado: (2017)

Chemokine Binding to Tenascin-C Influences Chemokine-Induced Immune Cell Migration
por: Domaingo, Alissa, et al.
Publicado: (2023)

Legal but lethal: functional protein aggregation at the verge of toxicity
por: Falsone, Angelika, et al.
Publicado: (2015)

DecoyFinder, a tool for finding decoy molecules
por: Adrià, Cereto Massagué, et al.
Publicado: (2012)

Affinity and Specificity for Binding to Glycosaminoglycans Can Be Tuned by Adapting Peptide Length and Sequence
por: Crijns, Helena, et al.
Publicado: (2021)

Monomeric and Dimeric CXCL8 Are Both Essential for In Vivo Neutrophil Recruitment
por: Das, Sandhya Thulasi, et al.
Publicado: (2010)

CXCL13, CXCL10 and CXCL8 as Potential Biomarkers for the Diagnosis of Neurosyphilis Patients
por: Wang, Cuini, et al.
Publicado: (2016)

CXCL8, CXCL9, CXCL10, and CXCL11 as biomarkers of liver injury caused by chronic hepatitis B
por: Yu, Xin, et al.
Publicado: (2022)

CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance
por: Dong, Xiaoyan, et al.
Publicado: (2021)

Tumor Endothelium Marker-8 Based Decoys Exhibit Superiority over Capillary Morphogenesis Protein-2 Based Decoys as Anthrax Toxin Inhibitors
por: Cai, Chenguang, et al.
Publicado: (2011)

CXCL8 – The First Chemokine
por: Baggiolini, Marco
Publicado: (2015)

The neurotransmitter serotonin interrupts α-synuclein amyloid maturation
por: Falsone, S. Fabio, et al.
Publicado: (2011)

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking
por: Mysinger, Michael M., et al.
Publicado: (2012)

The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer
por: Łukaszewicz-Zając, Marta, et al.
Publicado: (2020)

TRAIL Death Receptor-4, Decoy Receptor-1 and Decoy Receptor-2 Expression on CD8(+ )T Cells Correlate with the Disease Severity in Patients with Rheumatoid Arthritis
por: Bisgin, Atil, et al.
Publicado: (2010)

Chemokine decoy receptors in inflammation
por: Graham, G
Publicado: (2005)

Cellular decoys distract coronavirus
por: Bradley, David
Publicado: (2020)

Impacts of Visualizations on Decoy Effects
por: Jeong, Yuin, et al.
Publicado: (2021)

High Levels of CXCL8 and Low Levels of CXCL9 and CXCL10 in Women with Maternal RhD Alloimmunization
por: Schettini, Juliana Araújo de Carvalho, et al.
Publicado: (2017)

Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10
por: Caetano, Ana J, et al.
Publicado: (2023)

In Vivo Imaging of Transiently Transgenized Mice with a Bovine Interleukin 8 (CXCL8) Promoter/Luciferase Reporter Construct
por: Stellari, Fabio Franco, et al.
Publicado: (2012)

Expression and migratory analysis of 5 human uveal melanoma cell lines for CXCL12, CXCL8, CXCL1, and HGF
por: Di Cesare, Sebastian, et al.
Publicado: (2007)

Discovery of IL-8/CXCL8 (The Story from Frederick)
por: Yoshimura, Teizo
Publicado: (2015)

The Chemokine CXCL8 in Carcinogenesis and Drug Response
por: Gales, Dominique, et al.
Publicado: (2013)

The significance of chemokine CXCL-8 in esophageal carcinoma
por: Łukaszewicz-Zając, Marta, et al.
Publicado: (2020)

Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1
por: Jiang, Shinn-Jong, et al.
Publicado: (2015)

The chemokines IP-10/CXCL10 and IL-8/CXCL8 are potential novel biomarkers of warm autoimmune hemolytic anemia
por: Branch, Donald R., et al.
Publicado: (2022)

The neural correlates of the decoy effect in decisions
por: Hu, Jianping, et al.
Publicado: (2014)

Molecular decoys: antidotes, therapeutics and immunomodulators
por: Gershoni, Jonathan M
Publicado: (2008)

TNF Decoy Receptors Encoded by Poxviruses
por: Alvarez-de Miranda, Francisco Javier, et al.
Publicado: (2021)

HNRNPA1 promotes recognition of splice site decoys by U2AF2 in vivo
por: Howard, Jonathan M., et al.
Publicado: (2018)

Prognostic and Pathophysiologic Significance of IL-8 (CXCL8) in Biliary Atresia
por: Godbole, Nimish, et al.
Publicado: (2021)

Correction: Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex
por: Helmer, Dorothea, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lhi2fq4tnvdrig2vl1acd4pvcj