Novel Spontaneous Deletion of Artemis Exons 10 and 11 in Mice Leads to T- and B-Cell Deficiency

Here we describe a novel, spontaneous, 4035 basepairs long deletion in the DNA cross-link repair 1C (Dclre1c)-locus in C57BL/6-mice, which leads to loss of exons 10 and 11 of the gene encoding for Artemis, a protein involved into V(D) J-recombination of antigen receptors of T and B cells. While seve...

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Detalles Bibliográficos
Autores principales: Barthels, Christian, Puchałka, Jacek, Racek, Tomas, Klein, Christoph, Brocker, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775751/
https://www.ncbi.nlm.nih.gov/pubmed/24069355
http://dx.doi.org/10.1371/journal.pone.0074838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775751/
https://www.ncbi.nlm.nih.gov/pubmed/24069355
http://dx.doi.org/10.1371/journal.pone.0074838

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